Endocrine Abstracts

PNETs represent the leading cause of mortality in MEN1 patients. Yet, their characteristics, behaviour, and therefore management, are still uncertain.The aim of this study was to describe the main clinical characteristics of NETs in MEN1, and to compare them with sporadic NETs.We investigated 164 patients with PNETs retrospectively, treated in one centre from 2004–2016. We identified 15 (9.1%) patients with MEN1. All patients ...

Introduction: Calcitonin secreting neuroendocrine tumors (NET) are rare and not well recognized. Due to many similarities, it is sometimes difficult to differentiate them from medullary thyroid carcinoma (MTC), which can hamper choice of proper therapy. We investigated our group of patients with this type of NET in terms of diagnosis and biology.Patients and Methods: We analyzed 38 patients with calcitonin secreting NET (5% of all our patients with NET)....

40-year-old female patient presented with acromegaly in 2008 (GH 61 (g/L, IGF-1 774 ng/ml PRL 1500 mU/L). Macro-adenoma invading the right cavernous sinus was found on MRI and she underwent two pituitary surgeries revealing sparsely granulated GH adenoma with scattered PRL cells, low Ki 67 and negative p53 immuno-staining. Her second cousin was treated for macro prolactinoma. Both patients tested negative for germline mutations in the AIP and menin genes. Treatment with somato...

Objective: Hypopituitarism is a rare disease,a pituitary adenoma and is treatment being the most common cause of it. In recent years there is increased reporting of rare causes of hypopituitarism acquired in adulthood, such as other sellar and parasellar masses, brain damage caused by radiation and traumatic brain injury (TBI), vascular lesions, infiltrative/immunological/inflammatory diseases and infectious diseases. Aim of our study was to increase the awareness to these rar...

Objective: Congenital hypogonadotropic hypogonadism (CHH) results from isolated GnRH deficiency and may present with normal sense of smell (nCHH), anosmia (Kallmann syndrome, KS) or in syndromic forms. Genetic defects are identified in approximately half of CHH cases and oligogenicity is noted in almost 10%. Further, spontaneous reversal of is seen in 15% of patients.Methods: We analyzed the clinical characteristics of 37 Serbian CHH probands (34 sporadi...

Activation of hypothalamo-pituitary-adrenal (HPA) axis is a common feature of endocrine responses to stress, with cortisol secretion as an end product of this activation. Acute rise in cortisol level during stress is of utmost importance for metabolic adjustments, immune system adaptations, cardiovascular responses and muscle tissue remodeling. But since chronic hypercortisolism has many deleterious effects, scientific interest has started focusing around different biological ...

Adrenocortical carcinoma (ACC) is rare malignancy associated with limited treatment options and poor prognosis. The aim of this study is to review clinical characteristics and survival of patients with ACC in single centre. We retrospectively analysed 60 patients (37 female and 23 males) with pathologically confirmed ACC who were treated at our institution between January 2005 and December 2014. Staging was performed according to European Network Study of Adrenal Tumours (ENS@...

Introduction: Medullary thyroid carcinoma (MTC) is a malignant neoplasm derived from the parafollicular cells of the thyroid gland. Approximately 25% of them are caused by germline mutations of the RET gene, presenting as a part of FMTC, MEN2A or MEN2B syndrome.Design of the study: We analysed 213 consecutive patients with MTC (142 females, 71 males, age 6–78, mean 45 years), treated in a single centre from 2004 to 2014. Direct DNA sequenci...

Multiple endocrine neoplasia type 1 (MEN1) syndrome is an autosomal dominant familial tumor syndrome characterised by varying combinations of endocrine and non-endocrine tumors. Breast cancer is the most frequently diagnosed cancer in women, but presence of breast cancer in MEN1 is extremely rare.A 36-year-old patient has been diagnosed with primary hyperparathyroidism, breast cancer and hyperprolactinemia due to a pituitary macroprolactinoma. Treatment ...

The co-secretion of GHRH and GH has been described previously in a patient with GHRH producing pituitary somatotroph adenoma. Here we present a patient with MEN1 and ectopic secretion of both GHRH and GH from a neuroendocrine lung tumor.A 52-year-old woman was diagnosed in 2009 with two lung tumors, 4 cm right upper lobe tumor, and 2 cm left lower lobe tumor. Owing to a mild coarsening of facial features, acromegaly was suspected. Endocrine studies showe...